TitleDepressive disorders during pregnancy: prevalence and risk factors in a large urban sample.
Publication TypeJournal Article
Year of Publication2010
AuthorsMelville JL, Gavin A, Guo Y, Fan M-Y, Katon WJ
JournalObstet Gynecol
Date Published2010 Nov
KeywordsAdolescent, Adult, Depressive Disorder, Female, Humans, Middle Aged, Panic Disorder, Pregnancy, Pregnancy Complications, Prevalence, Risk Factors, Spouse Abuse, Stress, Psychological, Suicide, Urban Population, Young Adult

OBJECTIVE: To estimate the prevalence of major and minor depression, panic disorder, and suicidal ideation during pregnancy while also identifying factors independently associated with antenatal depressive disorders.

METHODS: In this prospective study, participants were 1,888 women receiving ongoing prenatal care at a university obstetric clinic from January 2004 through January 2009. Prevalence of psychiatric disorders was measured using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria based on the Patient Health Questionnaire. Multiple logistic regression identified factors associated with probable major depressive disorder and any depressive disorder.

RESULTS: Antenatal depressive disorders were present in 9.9% with 5.1% (97) meeting criteria for probable major depression and 4.8% (90) meeting criteria for probable minor depression. Panic disorder was present in 3.2% (61), and current suicidal ideation was reported by 2.6% (49). Among patients with probable major depression, 29.5% (28) reported current suicidal ideation. Psychosocial stress (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.21-1.36), domestic violence (OR 3.45; 95% CI 1.46-8.12), chronic medical conditions (OR 3.05; 95% CI 1.63-5.69), and race (Asian: OR 5.81; 95% CI 2.55-13.23; or African American: OR 2.98; 95% CI 1.24-7.18) each significantly increased the odds of probable antepartum major depressive disorder, whereas older age (OR 0.92; 95% CI 0.88-0.97) decreased the odds. Factors associated with odds of any depression were similar overall except that Hispanic ethnicity (OR 2.50; 95% CI 1.09-5.72) also independently increased the odds of any depression.

CONCLUSION: Antenatal major and minor depressive disorders are common and significantly associated with clinically relevant and identifiable risk factors. By understanding the high point prevalence and associated factors, clinicians can potentially improve the diagnosis and treatment rates of serious depressive disorders in pregnant women.


Alternate JournalObstet Gynecol
PubMed ID20966690
PubMed Central IDPMC3068619
Grant List1KL2RR025015-01 / RR / NCRR NIH HHS / United States
K24 MH069471 / MH / NIMH NIH HHS / United States
KL2 RR025015 / RR / NCRR NIH HHS / United States
KL2 RR025015-01 / RR / NCRR NIH HHS / United States
R01 MH085668 / MH / NIMH NIH HHS / United States
R24 HD042828 / HD / NICHD NIH HHS / United States
R24 HD042828-10 / HD / NICHD NIH HHS / United States