%0 Journal Article %J Academic Pediatrics %D 2023 %T Multiple perspectives on motivating parents in pediatric primary care to initiate participation in parenting programs %A Mehus, Christopher J. %A Buchanan, Gretchen %A Ballard, Jaime %A Berkel, Cady %A Borowsky, Iris Wagman %A Estrada, Yannine %A Klein, Jonathan D. %A Kuklinski, Margaret %A Prado, Guillermo %A Shaw, Daniel %A Smith, Justin D. %B Academic Pediatrics %V Advance online publication. doi: 10.1016/j.acap.2023.07.020 %8 08/2023 %G eng %U https://doi.org/10.1016/j.acap.2023.07.020 %R 10.1016/j.acap.2023.07.020 %0 Journal Article %J Prevention Science %D 2022 %T State-of-the-art in substance use prevention and early intervention: Applications to pediatric primary care settings %A Matson, Pamela A. %A Ridenour, Ty %A Ialongo, Nicholas %A Spoth, Richard %A Prado, Guillermo %A Hammond, Christopher J. %A Hawkins, J D %A Adger, Hoover, Jr. %B Prevention Science %V 23 %P 204-211 %G eng %0 Journal Article %J American Journal of Preventive Medicine %D 2016 %T Primary health care: Potential home for family-focused preventive interventions %A Leslie, Laurel K. %A Mehus, Christopher J. %A Hawkins, J D %A Boat, Thomas %A McCabe, M A %A Barkin, Shari %A Perrin, Ellen %A Metzler, Carol %A Prado, Guillermo %A Tait, V. Fan %A Brown, Randall %A Beardslee, William %B American Journal of Preventive Medicine %V 51 %P S106-S118 %G eng %0 Journal Article %J Am J Public Health %D 2013 %T Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology. %A Brody, Gene H %A Beach, Steven R H %A Hill, Karl G %A Howe, George W %A Prado, Guillermo %A Fullerton, Stephanie M %K Adolescent %K Child %K Gene-Environment Interaction %K Genetics, Behavioral %K Humans %K Molecular Biology %K Psychopathology %K Randomized Controlled Trials as Topic %K Research Design %K Risk Factors %K Substance-Related Disorders %X

In this essay, we describe a new era of public health research in which prevention science principles are combined with genomic science to produce gene × intervention (G × I) research. We note the roles of behavioral and molecular genetics in risk and protective mechanisms for drug use and psychopathology among children and adolescents, and the results of first-generation genetically informed prevention trials are reviewed. We also consider the need for second-generation research that focuses on G × I effects on mediators or intermediate processes. This research can be used to further understanding of etiological processes, to identify individual differences in children's and adolescents' responses to risk, and to increase the precision of prevention programs. We note the caveats about using genetic data to select intervention participants.

%B Am J Public Health %V 103 Suppl 1 %P S19-24 %8 2013 Oct %G eng %R 10.2105/AJPH.2012.301080