%0 Journal Article %J Gen Hosp Psychiatry %D 2012 %T Depression in pregnancy is associated with preexisting but not pregnancy-induced hypertension. %A Katon, Wayne J %A Russo, Joan E %A Melville, Jennifer L %A Katon, Jodie G %A Gavin, Amelia R %K Adult %K Antidepressive Agents %K Depression %K Female %K Humans %K Hypertension %K Pregnancy %K Pregnancy Complications %K Prospective Studies %K Regression Analysis %K Surveys and Questionnaires %K Young Adult %X

BACKGROUND: The aim was to examine whether depression is associated with preexisting hypertension or pregnancy-induced hypertension in a large sample of women attending a university-based obstetrics clinic.

METHODS: In this prospective study, participants were 2398 women receiving ongoing prenatal care at a university-based obstetrics clinic from January 2004 through January 2009. Prevalence of depression was measured using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria based on the Patient Health Questionnaire-9 as well as the self-reported use of antidepressant medication. Evidence of preexisting hypertension, pregnancy-induced hypertension and preeclampsia/eclampsia was determined by obstetrician International Classification of Diseases, Ninth Revision codes. Logistic regression was used to quantify the association between hypertension in pregnancy and antenatal depression.

RESULTS: After adjusting for sociodemographic variables, chronic medical conditions, smoking and prior pregnancy complications, women with preexisting hypertension had an increased risk of any depression (minor, major, use of antidepressants) [odds ratio (OR)=1.55, 95% confidence interval (CI) 1.08-2.23) and major depression and/or use of antidepressants (OR=1.65, 95% CI 1.10-2.48) compared to women without hypertension. No differences were seen in risk of depression in women with pregnancy-induced hypertension or preeclampsia/eclampsia compared to those without hypertension.

CONCLUSION: Women with preexisting hypertension, but not pregnancy-induced hypertension, are more likely to meet criteria for an antenatal depressive disorder and/or to be treated with antidepressants and could be targeted by obstetricians for screening for depression and enhanced treatment.

%B Gen Hosp Psychiatry %V 34 %P 9-16 %8 2012 Jan-Feb %G eng %N 1 %R 10.1016/j.genhosppsych.2011.09.018 %0 Journal Article %J J Womens Health (Larchmt) %D 2011 %T Diabetes and depression in pregnancy: is there an association? %A Katon, Jodie G %A Russo, Joan %A Gavin, Amelia R %A Melville, Jennifer L %A Katon, Wayne J %K Adult %K Attitude to Health %K Cohort Studies %K Comorbidity %K Cross-Sectional Studies %K Depression %K Diabetes, Gestational %K Female %K Humans %K Pregnancy %K Pregnancy in Diabetics %K Prenatal Care %K Prevalence %K Prospective Studies %K Quality of Life %K Risk Factors %K United States %K Women's Health %K Young Adult %X

BACKGROUND: Prior studies have reported inconsistent findings regarding the association of antenatal depression with pregnancy-related diabetes. This study examined the association of diabetes and antenatal depression.

METHODS: We conducted a cross-sectional analysis of baseline data from a prospective cohort study of pregnant women receiving prenatal care at a single University of Washington Medical Center clinic between January 2004 and January 2009. The primary exposure was diabetes in pregnancy (no diabetes, preexisting diabetes, or gestational diabetes [GDM]). Antenatal depression was defined by the Patient Health Questionnaire-9 (PHQ-9) score or current use of antidepressants. Antenatal depression was coded as (1) any depression (probable major or minor depression by PHQ-9 or current antidepressant use) and (2) major depression (probable major depression by PHQ-9 or current antidepressant use). Logistic regression was used to quantify the association between diabetes in pregnancy and antenatal depression.

RESULTS: The prevalences of preexisting diabetes, GDM, any antenatal depression, and major antenatal depression were 9%, 18%, 13.6%, and 9.8%, respectively. In the unadjusted analysis, women with preexisting diabetes had 54% higher odds of any antenatal depression compared to those without diabetes (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.08-2.21). After adjusting for important covariates the association was attenuated (OR 1.16, 95% CI 0.79-1.71). Results were similar for antenatal major depression. GDM was not associated with increased odds for any antenatal depression or antenatal major depression.

CONCLUSIONS: Neither preexisting diabetes nor GDM was independently associated with increased risk of antenatal depression.

%B J Womens Health (Larchmt) %V 20 %P 983-9 %8 2011 Jul %G eng %N 7 %R 10.1089/jwh.2010.2662