%0 Journal Article %J Prev Sci %D 2012 %T Maternal early life risk factors for offspring birth weight: findings from the add health study. %A Gavin, Amelia R %A Thompson, Elaine %A Rue, Tessa %A Guo, Yuqing %K Adolescent %K Child Abuse %K Depression %K Factor Analysis, Statistical %K Female %K Humans %K Infant, Low Birth Weight %K Infant, Newborn %K Longitudinal Studies %K Mothers %K Risk Factors %K Smoking %K Social Class %K Substance-Related Disorders %X

The aim of this study was to examine the pathways that link mothers' early life socio economic status (SES) and mothers' experience of childhood maltreatment with birth weight among their later born offspring. Data were drawn from a nationally representative longitudinal survey of school-aged respondents, initially enrolled during adolescence in Wave I (1994-1995) and Wave II (1996) of the National Longitudinal Study of Adolescent Health and followed-up in adulthood in Wave III (2001-2002). Data on offspring birth weight were obtained from nulliparous females (Nā€‰=ā€‰1,897) who had given birth between Waves II and III. Analyses used structural equation modeling to examine the extent to which early life maternal risk predicted offspring birth weight, and demonstrated that maternal childhood SES and maternal childhood maltreatment predicted offspring birth weight through several mediated pathways. First, maternal adolescent substance use and prenatal cigarette use partially mediated the association between maternal childhood SES and offspring birth weight. Second, maternal adolescent depressive symptoms and adult SES partially mediated the association between maternal childhood SES and offspring birth weight. Third, adult SES partially mediated the association between maternal childhood SES and offspring birth weight. Fourth, maternal adolescent substance use and prenatal cigarette use partially mediated the association between maternal childhood maltreatment and offspring birth weight. Finally, maternal adolescent depressive symptoms and adult SES partially mediated the association between maternal childhood maltreatment and offspring birth weight. To our knowledge, this is the first study to identify maternal childhood maltreatment as an early life risk factor for offspring birth weight among a nationally representative sample of young women, and to demonstrate the mechanisms that link childhood SES and maltreatment to offspring birth weight. These findings suggest the importance of designing and implementing prevention and intervention strategies to address early life maternal social conditions in an effort to improve inter generational child health at birth.

%B Prev Sci %V 13 %P 162-72 %8 2012 Apr %G eng %N 2 %R 10.1007/s11121-011-0253-2 %0 Journal Article %J J Womens Health (Larchmt) %D 2012 %T Mediators of adverse birth outcomes among socially disadvantaged women. %A Gavin, Amelia R %A Nurius, Paula %A Logan-Greene, Patricia %K Adolescent %K Adult %K Cohort Studies %K Diagnostic and Statistical Manual of Mental Disorders %K Female %K Gestational Age %K Health Behavior %K Healthcare Disparities %K Humans %K Insurance Coverage %K Mental Disorders %K Middle Aged %K Pregnancy %K Pregnancy Outcome %K Pregnant Women %K Prenatal Care %K Prospective Studies %K Social Class %K Stress, Psychological %K Substance-Related Disorders %K Surveys and Questionnaires %K United States %K Vulnerable Populations %X

BACKGROUND: Numerous studies find that socially disadvantaged women are more likely than socially advantaged women to deliver infants that weigh less than normal and/or are born weeks prior to their due date. However, little is known about the pathways that link maternal social disadvantage to birth outcomes. Using data from a prospective cohort study, we examined whether antenatal psychosocial stress, substance use, and maternal health conditions in pregnancy mediated the pathway between maternal social disadvantage and birth outcomes.

METHODS: Analyses used structural equation modeling to examine data from a community clinic-based sample (n=2168) of pregnant women who completed questionnaires assessing psychosocial functioning and health behaviors as well as sociodemographic characteristics, which were matched with subsequent birth outcome data.

RESULTS: Analyses revealed maternal social disadvantage predicted poorer birth outcomes through a mediated pathway including maternal health conditions in pregnancy.

CONCLUSIONS: The findings demonstrate that maternal social disadvantage is associated with poor health status in pregnancy, which in turn adversely affects birth outcomes. Results argue for more systematic attention to the roles of social disadvantage, including life course perspectives that trace social disadvantage prior to and through pregnancy.

%B J Womens Health (Larchmt) %V 21 %P 634-42 %8 2012 Jun %G eng %N 6 %R 10.1089/jwh.2011.2766 %0 Journal Article %J Arch Gen Psychiatry %D 2010 %T A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. %A Grote, Nancy K %A Bridge, Jeffrey A %A Gavin, Amelia R %A Melville, Jennifer L %A Iyengar, Satish %A Katon, Wayne J %K Cross-Cultural Comparison %K Depressive Disorder %K Female %K Fetal Growth Retardation %K Humans %K Infant, Low Birth Weight %K Infant, Newborn %K Mass Screening %K Obstetric Labor, Premature %K Pregnancy %K Pregnancy Complications %K Prospective Studies %K Risk %K Socioeconomic Factors %X

CONTEXT: Maternal depressive symptoms during pregnancy have been reported in some, but not all, studies to be associated with an increased risk of preterm birth (PTB), low birth weight (LBW), and intrauterine growth restriction (IUGR).

OBJECTIVE: To estimate the risk of PTB, LBW, and IUGR associated with antenatal depression.

DATA SOURCES AND STUDY SELECTION: We searched for English-language and non-English-language articles via the MEDLINE, PsycINFO, CINAHL, Social Work Abstracts, Social Services Abstracts, and Dissertation Abstracts International databases (January 1980 through December 2009). We aimed to include prospective studies reporting data on antenatal depression and at least 1 adverse birth outcome: PTB (<37 weeks' gestation), LBW (<2500 g), or IUGR (<10th percentile for gestational age). Of 862 reviewed studies, 29 US-published and non-US-published studies met the selection criteria.

DATA EXTRACTION: Information was extracted on study characteristics, antenatal depression measurement, and other biopsychosocial risk factors and was reviewed twice to minimize error.

DATA SYNTHESIS: Pooled relative risks (RRs) for the effect of antenatal depression on each birth outcome were calculated using random-effects methods. In studies of PTB, LBW, and IUGR that used a categorical depression measure, pooled effect sizes were significantly larger (pooled RR [95% confidence interval] = 1.39 [1.19-1.61], 1.49 [1.25-1.77], and 1.45 [1.05-2.02], respectively) compared with studies that used a continuous depression measure (1.03 [1.00-1.06], 1.04 [0.99-1.09], and 1.02 [1.00-1.04], respectively). The estimates of risk for categorically defined antenatal depression and PTB and LBW remained significant when the trim-and-fill procedure was used to correct for publication bias. The risk of LBW associated with antenatal depression was significantly larger in developing countries (RR = 2.05; 95% confidence interval, 1.43-2.93) compared with the United States (RR = 1.10; 95% confidence interval, 1.01-1.21) or European social democracies (RR = 1.16; 95% confidence interval, 0.92-1.47). Categorically defined antenatal depression tended to be associated with an increased risk of PTB among women of lower socioeconomic status in the United States.

CONCLUSIONS: Women with depression during pregnancy are at increased risk for PTB and LBW, although the magnitude of the effect varies as a function of depression measurement, country location, and US socioeconomic status. An important implication of these findings is that antenatal depression should be identified through universal screening and treated.

%B Arch Gen Psychiatry %V 67 %P 1012-24 %8 2010 Oct %G eng %N 10 %R 10.1001/archgenpsychiatry.2010.111