This case-controlled study examines the maternal early-life risk predictors of offspring low birth weight and prematurity in a sample of 200 women who received prenatal care services at a university-based prenatal care clinic and delivery hospital, including examination of mediated pathways linking early-life risks to offspring birth weight and prematurity. This patient-oriented research addresses significant gaps in maternal preclinical factors theorized to convey risk associated with prior stress and adversity leading to disparities related to adverse birth outcomes, with demonstrated negative consequences continuing through development. Findings that help close this translational gap are essential to effectively targeting risk factors prior to and within the antenatal period, to curb what is currently an increasing trend in negative birth outcomes.

Center for the Studies of Demography & Ecology
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